However, the most recent findings show that it is an indirect process. The process is in fact controlled by arginine's ability to secrete the intestinal hormone GLP-1, which subsequently affects insulin secretion. Mice without GLP-1 receptors aren’t affected to the same extent by arginine. There is absolutely no perceptible improvement in glucose insulin or metabolism secretion, confirming our hypothesis of a close biological connection between arginine and GLP-1, says Christoffer Clemmensen, who executed the biological experiments in america using a special pet model where in fact the receptor for GLP-1 can be genetically inactivated.Being overweight impairs our ability to deal with a patient’s leukemia, the most typical cancer occurring in children, explains Dr. Mittelman. We’ve found that excess fat cells secrete chemical messengers that trigger leukemia cells to migrate into the fat. Fat cells secrete factors that secure leukemia cells from chemotherapy also, making the disease more difficult to take care of. Leo Mascarenhas, MD, MS, is usually director of the Clinical Trials Office in the Children’s Middle for Cancer and Bloodstream Diseases and Principal Investigator for the National Malignancy Institute funded Children’s Oncology Group grant at Children’s Hospital LA.